Critical Need for Appropriate Mucosal Sample Collection to Determine Relational Animal Pharmacokinetic–Pharmacodynamic Models in HIV Prevention
Critical Need for Appropriate Mucosal Sample Collection to Determine Relational Animal Pharmacokinetic–Pharmacodynamic Models in HIV Prevention
Leslie J Marshall,J. Cummins,3 Authors,Angela Kashuba, on behalf of the HIV Prevention Pharmacol
2013 · DOI: 10.1089/aid.2013.0142
AIDS Research and Human Retroviruses · 0 Citations
TLDR
Two protocols were developed for humanized bone marrow-liver-thymus (BLT) mouse and nonhuman primate (NHP) studies to support PK-PD studies in relevant animal models of HIV transmission and the prodrug tenofovir disoproxyl fumarate (TDF) was selected for the studies.