Critical Imbalance of TNF-α and Soluble TNF Receptor 1 in a Patient with Macrophage Activation Syndrome: Potential Implications for Diagnostics and Treatment
Critical Imbalance of TNF-α and Soluble TNF Receptor 1 in a Patient with Macrophage Activation Syndrome: Potential Implications for Diagnostics and Treatment
A. Flammiger,W. Fiedler,3 Authors,M. Binder
2012 · DOI: 10.1159/000338179
Acta Haematologica · 28 Citations
TLDR
A 27-year-old critically ill patient with refractory MAS and an insufficient negative feedback regulation, resulting in an overwhelming inflammatory response is reported on, where a personalized treatment with soluble TNF receptor etanercept resulted in a durable remission.