Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
Renaud Poincloux,O. Collin,4 Authors,P. Chavrier
2011 · DOI: 10.1073/pnas.1010396108
Proceedings of the National Academy of Sciences of the United States of America · 311 Citations
TLDR
Findings support a model whereby actomyosin-based uropod contractility generates traction forces on the β1 integrin adhesion system to drive cell propulsion within the 3D matrix, with no contribution of lamellipodia extension or blebbing to movement.