Computational investigation of hsa-mir-196a-2 targetome pathway and its SNP function in patients with gastric carcinoma: probable association between alleles and patients prognosis

environments, computer-generated navigation systems, cognitive tutors, decision aids, guidelines for eyewitness interrogation, neuro-marketing, speech recognition and synthesis, team-oriented technology, cognitive war, humancomputer interface, and intelligent therapies. There are several studies on the clinical application of cognitive science in cancer and chemo brain curing. In the first part of the paper the effect of mind on ordering the disordered body members and cellular signaling pathway are reviewed. Cell signaling such as Wnt Signaling, Hedgehog signaling, Notch signaling, neurotensin signaling are component of a complex communication system among cell that govern activities and actions such as development, tissue repairing, and immunity as well as homeostasis. In the second part of the paper the effect of cognitive images, cognitive concept of colors, emotional intelligence, cognitive therapy, and social mind on the minds of patient with cancer and chemo brain which is a cognitive dysfunction are reviewed. Fig. 1 shows the aim of this research. The organization of the rest of this paper is as follows: Section 2 reviews the related works. Section 3 summarizes this paper. State of the Art: The first foot print of cognitive science that we can refer to is psycho-oncology, which is an interdisciplinary study at the intersection of lifestyle, psychology and oncology. The major specialities in psycho-oncology are clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. The field is concerned both with the effects of cancer on a person's psychological health as well as the social and behavioral factors that may affect the disease process of cancer and/or the remission of it. Upon defining psychooncology, mind-body therapy for cancer in a reversing manner is presented. Cognitive Therapy (CT) as a part of mind therapy is presented for treating distress among cancer patients. CT is used to promote coping and adaptation, to control fear of recurrence, to think positive, to analyze the vital role of empathy in cancer problem solving. Several common mindebody therapies that have positive influence on cancer curing include yoga, praying, hypnotherapy, cognitive behavioral therapy, meditation, guided imagery, and biofeedback training. Beside positive effect of mind-body therapy on cancer curing, there are several other healing application of this therapy on disease improvement such as mind-body therapeutic program for infertile women, mindebody therapies for functional bowel disorders, and effect of positive emotions on gene expression in humans and an animal model. For example, laughter altered the expression of genes involved in immune reactions, cell signaling, the cell cycle, apoptosis, and cell adhesion. Furthermore, colors which are a different wave-lengths of light acts on the body by two pathways include the primary optic tract that governs visual perception and responses whereas the retinohypothalamic tract that governs circadian, endocrine, and neurobehavioral function. Therefore it affects the primary body functions including growth, sleep, appetite, circulation, nervous, mental and emotional state, and immune system. For example, colors are able to trigger hormone production and as a result influence the entire complex system of the body. Treatment with colored light is named color therapy. It achieved very significant healing results such as changes of blood oxygenation in the brain and muscles. Also there is a body of evidence examining the association between Emotional Intelligence (EI), personality, and its relation to health-related quality of life in patients with cancer and chemo brain. EI helps the patient with cancer in finding awareness of self, actions of self, awareness of others, interaction with others, and resilience. Predefined guided cognitive images through social mind process may consider a future proper tool for controlling and curing disease like cancer. Conclusions: Cancer, a disease complex, needs a personalized therapy. Flavor of cognitive science with the main pillar as mind, recommended to be considered as a personalized therapy. In this paper the merits of cognitive science in cancer therapy will be discussed in two phases including effect of mind on ordering the disordered body members and cellular signaling pathway and the effect of cognitive images, cognitive concept of colors, emotional intelligence, cognitive therapy, and social mind on the minds of patient with cancer and chemo brain.