Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV‐1 protease
Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV‐1 protease
M. Altman,E. Nalivaika,2 Authors,B. Tidor
2008 · DOI: 10.1002/prot.21514
Proteins: Structure, Function, and Bioinformatics · 46 Citations
TLDR
Structural studies show strong similarities between natural and tighter‐binding designed peptide complexes, which may have implications in understanding the molecular mechanisms of drug resistance in HIV‐1 protease.