Cohesin association to replication sites depends on rad50 and promotes fork restart.
Cohesin association to replication sites depends on rad50 and promotes fork restart.
Mireille Tittel-Elmer,Armelle Lengronne,6 저자,J. Cobb
2012 · DOI: 10.1016/j.molcel.2012.07.004
Molecules and Cells · 125회 인용
TLDR
Cohesin enrichment at replication forks does not depend on γH2A(X) formation, which differs from its loading requirements at DNA double-strand breaks (DSBs), and Interestingly, cohesin loading at replication sites depends on the structural features of Rad50 that are important for bridging sister chromatids, including the CXXC hook domain and the length of the coiled-coil extensions.