Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.
Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.
E. Martegani,Marco Vanoni,5 Authors,Lilia Alberghina
1992 · DOI: 10.1002/j.1460-2075.1992.tb05274.x
EMBO Journal · 201 Citations
TLDR
The isolation of a mouse brain cDNA homologous to CDC25, called CDC25Mm, complements specifically point mutations and deletion/disruptions of the CDC25 gene and restores the cAMP levels and CDC25‐dependent glucose‐induced cAMP signalling in a yeast strain bearing a disruption of theCDC25 gene.