Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity
Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity
Chenghuan Song,Yongfang Zhang,7 Authors,Hao Wang
2021 · DOI: 10.1038/s41418-021-00865-1
Cell Death and Differentiation · 89 Citations
TLDR
Significant functional consequences of a circRNA–protein interaction are suggested, that circCwc27, by associating with the regulatory protein Pur-α, may act as a crucial player in AD pathogenesis and represent a promising AD therapeutic target with clinical translational potential.