Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.
Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.
Minghua Yang,Lizhi Cao,5 Authors,D. Tang
2013 · DOI: 10.1016/j.bcp.2013.05.013
Biochemical Pharmacology · 102 Citations
TLDR
It is shown that chloroquine, an anti-malarial drug, prevents lethality in mice with established endotoxemia or sepsis and suggests a new potential clinical use for this drug in the setting ofsepsis.