Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
E. Tran,S. Turcotte,10 Authors,S. Rosenberg
2014 · DOI: 10.1126/science.1251102
Science · 1,628 Citations
TLDR
Evidence is provided that a CD4+ T cell response against a mutated antigen can be harnessed to mediate regression of a metastatic epithelial cancer.