Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors.
Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors.
Zilan Zhou,C. Kennell,2 Authors,P. Tarapore
2017 · DOI: 10.1016/j.nano.2016.07.016
Nanomedicine: Nanotechnology, Biology and Medicine · 70 Citations
TLDR
This nanoparticle system was found to simultaneously deliver paclitaxel and miRi-221/222 to their intracellular targets, leading to inhibit proliferative mechanisms of miR- 221/222 and thus significantly enhancing the therapeutic efficacy of pac litaxel.