CEP55 promotes cilia disassembly through stabilizing Aurora A kinase

TLDR

These findings establish a cilia disassembly role for CEP55 in vivo and in vitro, coupling defects in ciliadisassembly to ciliopathy and further suggesting that proper cilia dynamics are critical for mammalian development.

Abstract

Zhang et al. identify CEP55 as a novel regulator of cilia disassembly. Their findings establish a cilia disassembly role for CEP55 in vivo and in vitro, coupling defects in cilia disassembly to ciliopathy and further suggesting that proper cilia dynamics are critical for mammalian development.