C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
Kyung‐Ha Lee,Peipei Zhang,18 Authors,J. Taylor
2016 · DOI: 10.1016/j.cell.2016.10.002
Cell · 607 Citations
TLDR
It is found that arginine-containing DPRs, polyGly-Arg (GR) and polyPro- Arg (PR), interact with RNA-binding proteins and proteins with low complexity sequence domains (LCDs) that often mediate the assembly of membrane-less organelles.
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