Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
S. Budhu,David A. Schaer,8 Authors,J. Wolchok
2017 · DOI: 10.1126/scisignal.aak9702
Science Signaling · 124 Citations
TLDR
Ex vivo three-dimensional collagen-fibrin gel cultures of dissociated B16 melanoma tumors recapitulated the in vivo suppression of antimelanoma immunity, rendering the dissociated tumor cells resistant to killing by cocultured activated, antigen-specific T cells.