BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
Lai Xu,Yue Wei,5 Authors,J. Harper
2003 · DOI: 10.1038/nature01985
Nature · 533 Citations
TLDR
Biochemical studies using the BTB protein MEL-26 and its genetic target MEI-1 indicate that BTB proteins merge the functional properties of Skp1 and F-box proteins into a single polypeptide.