Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition
Xiaolei Xie,Li Le,2 Authors,Junjie Zhang
2012 · DOI: 10.4161/auto.20250
Autophagy · 60 Citations
TLDR
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition, indicating that tumor protein 53 (TP53) is essential for the autophagy induction.