Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
K. Lassen,Petric Kuballa,21 Authors,R. Xavier
2014 · DOI: 10.1073/pnas.1407001111
Proceedings of the National Academy of Sciences of the United States of America · 365 Citations
TLDR
It is demonstrated how the T300A polymorphism leads to cell type- and pathway-specific disruptions of selective autophagy and suggest a mechanism by which this polymorphism contributes to disease.