Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.
M. DeBaun,E. Niemitz,A. Feinberg
2003 · DOI: 10.1086/346031
American Journal of Human Genetics · 922 Citations
TLDR
The first evidence, to the knowledge, is reported that ART is associated with a human overgrowth syndrome-namely, Beckwith-Wiedemann syndrome (BWS), similar to the large offspring syndrome reported in ruminants.