Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
J. Hugot,M. Chamaillard,17 Authors,G. Thomas
2001 · DOI: 10.1038/35079107
Nature · 5,702 Citations
TLDR
It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.