Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.
J. Menéndez,J. Menéndez,3 Authors,R. Lupu
2005 · DOI: 10.1093/ANNONC/MDI239
Annals of Oncology · 168 Citations
TLDR
Orlistat-induced FAS inhibition synergistically promoted apoptotic cell death when concurrently combined with trastuzumab as determined by an ELISA for histone-associated DNA fragments.
Cited Papers
Citing Papers