Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C

Mice are typically housed at environmental temperatures below thermoneutrality, whereas humans live near thermoneutrality. This difference affects energy physiology and, potentially, anti‐obesity drug efficacy. Here β3‐adrenergic agonist treatment at thermoneutrality (30°C) versus room temperature (22°C) is compared.