Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
A. Lazrak,Zhen Liu,Chou-Long Huang
2006 · DOI: 10.1073/pnas.0510609103
Proceedings of the National Academy of Sciences of the United States of America · 186 Citations
TLDR
It is reported that long WNK1 inhibited ROMK1 by stimulating its endocytosis, an adaptative response important for conservation of K+ during K+ deficiency and found that K+ restriction in rats increased whole-kidney transcript of long W NK1 while decreasing that of KS-WNK1.