Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.
A. Kauppinen,T. Suuronen,2 Authors,A. Salminen
2013 · DOI: 10.1016/j.cellsig.2013.06.007
Cellular Signalling · 914 Citations
TLDR
The molecular mechanisms of the antagonistic signaling between NF-κB and SIRT1 are examined and how this crosstalk controls inflammatory process and energy metabolism is described to induce the appearance of chronic inflammation in metabolic diseases.