An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
G. Eberl,Shana Marmon,3 Authors,D. Littman
2004 · DOI: 10.1038/ni1022
Nature Immunology · 995 Citations
TLDR
During fetal life the nuclear hormone receptor RORγt is expressed exclusively in and is required for the generation of LTi cells, which provide essential factors for activation of the mesenchyma in lymph node and Peyer's patch anlagen.