Amiloride analogs as ASIC1a inhibitors
Amiloride analogs as ASIC1a inhibitors
Tiandong Leng,H. Si,5 Authors,Z. Xiong
2016 · DOI: 10.1111/cns.12524
CNS Neuroscience & Therapeutics · 42 Citations
TLDR
ASIC1a, the predominant acid‐sensing ion channels (ASICs), is implicated in neurological disorders including stroke, traumatic spinal cord injury, and ALS and should have promising therapeutic potential for ASIC1a‐related diseases.
Abstract
ASIC1a, the predominant acid‐sensing ion channels (ASICs), is implicated in neurological disorders including stroke, traumatic spinal cord injury, and ALS. Potent ASIC1a inhibitors should have promising therapeutic potential for ASIC1a‐related diseases.