Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects
Alpha-1-Antitrypsin and a Broad Spectrum Metalloprotease Inhibitor, RS113456, Have Similar Acute Anti-Inflammatory Effects
A. Churg,J. Dai,9 Authors,J. Wright
2001 · DOI: 10.1038/labinvest.3780324
Laboratory Investigation · 147 Citations
TLDR
In this model of acute PMN mediated inflammation, a serine protease inhibitor and a metalloprotease inhibitor have similar anti-inflammatory properties, suggesting that inflammation is not mediated by proteolysis with generation of chemotactic matrix fragments, and that classic antiproteolysis probably does not play a role in suppression of inflammation.