Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
E. Muise,B. Azzolina,7 Authors,Kenny K. Wong
2008 · DOI: 10.1124/mol.108.044826
Molecular Pharmacology · 305 Citations
TLDR
Transcriptional profiling is used to identify genes encoding for secreted proteins the expression of which is regulated by PPARγ agonists and demonstrate that FGF21 protein is transcriptionally up-regulated in adipose tissue in vivo by PParγ agonist treatment and under a variety of physiological conditions, including fasting and high fat diet feeding.