Additive Effects of Angiotensin Receptor-Neprilysin Inhibitors and Sodium-Glucose Cotransporter 2 Inhibitors on Neurohormonal Inhibition Therapy in Severe HFrEF: A Systematic Review and Network Meta-analysis.
Additive Effects of Angiotensin Receptor-Neprilysin Inhibitors and Sodium-Glucose Cotransporter 2 Inhibitors on Neurohormonal Inhibition Therapy in Severe HFrEF: A Systematic Review and Network Meta-analysis.
Koji Suzuki,Sumika Osa,4 Authors,J. Kawakami
2026 · DOI: 10.1007/s40256-025-00784-3
American Journal of Cardiovascular Drugs · 0 Citations
TLDR
Evidence for the additive effects of SGLT2 inhibitors and ARNIs in severe HFrEF remains limited, and therefore, treatment intensification with these agents should be approached with caution.