Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Nagendra Singh,Ashish Gurav,10 Authors,V. Ganapathy
2014 · DOI: 10.1016/j.immuni.2013.12.007
Immunity · 2,031 Citations
TLDR
It is shown that Gpr109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells, and Niacr1(-/-) mice were susceptible to development of colonic inflammation and colon cancer.