Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy
Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy
L. Fischer,Yingjie Li,2 Authors,J. Glass
2012 · DOI: 10.1016/j.expneurol.2011.09.020
Experimental Neurology · 92 Citations
TLDR
It is concluded that the SOD1 knockout mouse is a model of oxidative stress-mediated motor axonopathy, and spinal motor neurons and motor and sensory nerve roots in these mice are preserved, even out to 18 months of age.