ATIVIDADE DO GENE LRRK2 NA DOENÇA DE PARKINSON: UM A REVISÃO DE LITERATURA
Murilo Santos De Souza,Isabela de Nazaré Tavares Cardoso Souza,Pablo Rodrigues Nunes de Souza,R. Oliveira
TLDR
A narrative literature review that searched for articles in the PubMed, Literatura Latino-Americana em Ciências da Saúde, and Scientific Electronic Library Online (SCIELO) databases finding the LRRK2 gene, which is associated with the intensification of kinase activity by the Leucine-Rich Repeat Kinase 2 gene, resulting in the aggregation and dispersion of alpha-synuclein, which leads to toxicity.
Abstract
Introduction . Parkinson's disease (PD) is a neurodegenerative disorder that is highly prevalent among the elderly. Its main cause is the degeneration of dopaminergic neurons in the substantia nigra due to the intracellular accumulation of alpha-synuclein, which compromises the nigrostriatal system. PD is associated with the intensification of kinase activity by the Leucine-Rich Repeat Kinase 2 (LRRK2) gene, resulting in the aggregation and dispersion of alpha-synuclein, which leads to toxicity. Method. This is a narrative literature review that searched for articles in the PubMed, Literatura Latino-Americana em Ciências da Saúde (LILACS), and Scientific Electronic Library Online (SCIELO) databases. The search was conducted by combining the following descriptors and Boolean operators: "alpha-synuclein protein" AND "LRRK2 gene" AND "Parkinson's disease". Results. The LRRK2 gene is involved in several cellular pathways, and when mutated, it can increase the likelihood of both familial