AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.
AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.
Rohan Gupta,A. Siddiqua,4 Authors,Sorabh Lakhanpal
2025 · DOI: 10.1007/s00210-025-04362-x
Naunyn-Schmiedeberg's Archives of Pharmacology · 0 Citations
TLDR
An integrative approach is used, combining gene expression analysis with machine learning, to identify novel gene candidates for IBD-related colorectal cancer and implicated AQP9 and IFITM1 in EMT, PI3K/Akt signaling, and immune infiltration pathways, highlighting their potential as diagnostic and therapeutic targets.