AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim,M. Kundu,B. Viollet,K. Guan
2011 · DOI: 10.1038/ncb2152
Nature Cell Biology · 6,266 Citations
TLDR
A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.