A vaccine targeting mutant IDH1 induces antitumour immunity
A vaccine targeting mutant IDH1 induces antitumour immunity
T. Schumacher,L. Bunse,24 Authors,M. Plattén
2014 · DOI: 10.1038/nature13387
Nature · 675 Citations
TLDR
It is demonstrated that IDH1(R132H) contains an immunogenic epitope suitable for mutation-specific vaccination and Peptides encompassing the mutated region are presented on major histocompatibility complexes (MHC) class II and induce mutation- specific CD4+ T-helper-1 (TH1) responses.