A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
T. Wölfel,M. Hauer,7 Authors,D. Beach
1995 · DOI: 10.1126/science.7652577
Science · 1,240 Citations
TLDR
Results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a.