A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.
B. Ronan,O. Flamand,14 Authors,B. Pasquier
2014 · DOI: 10.1038/nchembio.1681
Nature Chemical Biology · 427 Citations
TLDR
It is shown that the concomitant inhibition of Vps34 and mTOR, with SAR405 and the US Food and Drug Administration-approved mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines, indicating a potential clinical application in cancer.