A Synthetic Lethal Approach to Drug Targeting of G-Quadruplexes Based on CX-5461.
A Synthetic Lethal Approach to Drug Targeting of G-Quadruplexes Based on CX-5461.
Meiyu Jin,L. Hurley,Hongyan Xu
2023 · DOI: 10.1016/j.bmcl.2023.129384
Bioorganic & Medicinal Chemistry Letters · 15 Citations
TLDR
Screening results confirmed the synthetic lethal interaction between G4 stabilizers and HR genes and also uncovered other novel genetic interactions, including genes in other DNA damage repair pathways and genes in transcription, epigenetic, and RNA processing deficiencies.