A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
F. Clemente,Alexia Cardona,27 Authors,T. Kivisild
2014 · DOI: 10.1016/j.ajhg.2014.09.016
American Journal of Human Genetics · 125 Citations
TLDR
Evidence is provided of one of the strongest selective sweeps reported in humans that has driven this variant to high frequency in circum-Arctic populations within the last 6-23 ka despite associated deleterious consequences, possibly as a result of the selective advantage it originally provided to either a high-fat diet or a cold environment.