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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

M. Boyce,Kevin F. Bryant,8 Authors,Junying Yuan

2005 · DOI: 10.1126/SCIENCE.1101902
Science · 953 Citations

TLDR

Salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events and suggests that selective chemical inhibitors of eIF2α deph phosphorylation may be useful in diseases involving ER stress or viral infection.