A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
R. Duerr,K. Taylor,23 Authors,Judy H. Cho
2006 · DOI: 10.1126/science.1135245
Science · 2,958 Citations
TLDR
A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.