A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
Eiichiro Noguchi,Yoichiro Homma,2 Authors,Xiaojing Ma
2009 · DOI: 10.1038/ni.1722
Nature Immunology · 223 Citations
TLDR
It is found that 3020insC Nod2 mutant protein actively inhibited IL10 transcription and suppressedIL10 transcription by blocking phosphorylation of the nuclear ribonucleoprotein hnRNP-A1 via the mitogen-activated protein kinase p38.