(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation
(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation
F. Fiesel,M. Ando,17 Authors,W. Springer
2015 · DOI: 10.15252/embr.201540514
EMBO Reports · 164 Citations
TLDR
It is shown that pS65‐Ub is reversible and barely detectable under basal conditions, but rapidly induced upon mitochondrial stress in cells and amplified in the presence of functional Parkin.