(Leave blank) Award Number: W81XWH-08-1-0394 TITLE: Interplay of CREB and ATF2 in ionizing radiation-induced neuroendocrine differentiation of prostate cancer cells

It is shown that fractionated ionizing radiation (IR) induces differentiation of LNCaP prostate cancer cells into neuroendocrine (NE)-like cells, which are known to be implicated in prostate cancer progression, androgenindependent growth, and poor prognosis.