(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB
(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB
Yu‐Li Lin,Jen-kun Lin
1997 · DOI: 10.1124/MOL.52.3.465
549 Citations
TLDR
The results suggest that EGCG decreases the activity and protein levels of iNOS by reducing the expression ofiNOS mRNA and the reduction could occur through prevention of the binding of nuclear factor-kappaB to the iN OS promoter, thereby inhibiting the induction of i NOS transcription.