δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine
δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine
Felicia Klinger,Mirnes Bajrić,6 Authors,Xaver Koenig
2015 · DOI: 10.1111/bph.13262
British Journal of Pharmacology · 27 Citations
TLDR
Flupirtine was found to exert comparable actions at GABAA receptors and Kv7 channels in neurons of pain pathways, but not in hippocampus.
Abstract
The Kv7 channel activator flupirtine is a clinical analgesic characterized as ‘selective neuronal potassium channel opener’. Flupirtine was found to exert comparable actions at GABAA receptors and Kv7 channels in neurons of pain pathways, but not in hippocampus.