Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
L. Garofano,S. Migliozzi,19 저자,A. Iavarone
2021 · DOI: 10.1038/s43018-020-00159-4
Nature Cancer · 155회 인용
TLDR
The pathway-based classification of GBM informs survival and enables precision targeting of cancer metabolism, using single-cell RNA-sequencing data to classify glioblastomas along a metabolic axis of mitochondrial and glycolytic/plurimetabolic states and a neurodevelopmental axis of proliferative/progenitor and neuronal states.