Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.
Christopher D. Wiley,Michael C. Velarde,10 저자,J. Campisi
2016 · DOI: 10.1016/j.cmet.2015.11.011
Cell Metabolism · 1,007회 인용
TLDR
It is shown that several manipulations that compromise mitochondrial function in proliferating human cells induce a senescence growth arrest with a modified SASP that lacks the IL-1-dependent inflammatory arm, providing a mechanism by which mitochondrial dysfunction can drive aging phenotypes.