Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.
Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.
Ming-Hao Hu,Yu-Qing Wang,5 著者,Jia-Heng Tan
2018 · DOI: 10.1021/acs.jmedchem.7b01697
Journal of Medicinal Chemistry · 90 件の引用
TLDR
This work provides an encouraging example of a selective small molecule that can target one particular G-quadruplex structure, and the selective ligand might serve as an excellent anticancer agent.