Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
O. Loson,Zhiyin Song,Hsiuchen Chen,D. Chan
2013 · DOI: 10.1091/mbc.E12-10-0721
Molecular Biology of the Cell · 1,097 件の引用
TLDR
Mitochondrial fission requires recruitment of the GTPase Drp1 to mitochondria, but the molecules that mediate this recruitment have been disputed.
要旨
Mitochondrial fission requires recruitment of the GTPase Drp1 to mitochondria, but the molecules that mediate this recruitment have been disputed. Fis1, Mff, MiD49, and MiD51 can all recruit Drp1 to mitochondria and promote fission. MiD49 and MiD51 can promote mitochondrial fission, but their activity depends on cellular context.