Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Ann Boija,Isaac A. Klein,16 Autori,R. Young
2018 · DOI: 10.1016/j.cell.2018.10.042
Cell · 1,383 citazioni
TLDR
It is reported that diverse ADs form phase- separated condensates with the Mediator coactivator, suggesting that diverse TFs can interact with Mediator through the phase-separating capacity of their ADs and that formation of condensate with Mediation is involved in gene activation.